Viramune / Nevirapine

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Modified on 2009/10/14 21:45 by admin
Viramune, also known as nevirapine, is used to slow the progression of HIV, the virus that causes AIDS. Sometimes Viramune is used in combination with other HIV fighting drugs. As a preventative measure, the drug is often given to healthcare professionals and others who have been exposed to HIV positive substances. Viramune is manufactured by Boehringer Ingelheim.

Recently, researchers discovered that Viramune may cause severe damage to the liver, including liver failure resulting in death. Most adverse liver events occurred after patients took the drug for at least two weeks. Researchers recommend that doctors test and monitor liver function carefully if they plan on administering Viramune.

In August 2003, South Africa's Medicines Control Commission (MCC) announced it was considering withdrawing approval for Viramune for prevention of mother to child HIV transmission (MTCT) because of irregularities found in a recent study. According to the MCC, the US National Institute for Allergy and Infectious Diseases (NIAID) found that researchers made numerous data collection errors during the HIVNET 012 study in Uganda on the safety of Viramune.

In February 2004, Boehringer Ingelheim and the FDA notified healthcare professionals of new safety information added to the WARNINGS and Boxed Warning for Viramune. Severe, life-threatening, and in some cases fatal hepatotoxicity, including fulminant and cholestatic hepatitis, hepatic necrosis and hepatic failure, has been reported in patients treated with Viramune. These events are often associated with rash. Women, and patients with higher CD4 counts, are at increased risk of these hepatic events. Women with CD4 counts >250 cells/mm3, including pregnant women receiving chronic treatment for HIV infection, are at considerably higher risk of these events. Prodromal signs and symptoms, risk information and monitoring recommendations have been added to the labeling.

See your doctor if you have experienced serious side effects associated with Viramune. In addition, it may be important to contact an attorney who can help you protect your legal rights. Please keep in mind that there may be time limits within which you must commence suit.



See Also

  1. HIV & AIDS Drugs: Overview
  2. Liver Failure: Overview
  3. Liver Problems
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