Proleukin / Aldesleukin: Overview

Modified on 2009/10/14 21:50 by admin
Aldesleukin, known under the brand name Proleukin, is indicated for the treatment of metastatic renal cell carcinoma (kidney cancer) in adults. Proleukin was the first FDA-approved drug specifically designed to treat kidney cancer, a disease which accounts for about 10,000 deaths each year. Derived from genetically engineered bacteria that contain an analog of the human interleukin-2, Proleukin is a lymphokine involved in regulating immune response. The drug, administered intravenously, was approved by the U.S. Food and Drug Administration (FDA) in 1992 and is manufactured by Chiron Corporation.

Side effects include, but may not be limited to, arrhythmia, weight gain, respiratory illness, confusion, irritability, yellowing of the skin and eyes, nausea and dry skin.

A black box warning indicates that Proleukin should only be administered to patients with normal cardiac and pulmonary functions. Because of the possibility of severe adverse reactions, the FDA has labeled Proleukin to be administered intravenously only in a hospital setting under the supervision of a qualified physician experienced in the use of anticancer drugs. An intensive care facility and specialists skilled in cardiopulmonary or intensive care medicine must be available. The drug has been associated with capillary leak syndrome--the passing of plasma proteins and fluid outside the blood vessels. Capillary leak syndrome can result in hypotension and reduced circulation of blood in the organs, which may be severe and can result in death. Proleukin treatment has also been linked to bacterial infections and should be withheld from patients suffering from severe lethargy.

See your doctor if you have experienced an adverse reaction after being administered Proleukin. In addition, it may be important to contact an attorney who can help you protect your legal rights. Please keep in mind that there may be time limits within which you must commence suit.

See Also

  1. Cancer Drugs: Overview
  2. Arrhythmia: Overview
  3. Lung & Airway Disorders
  4. Nausea: Overview
  Name Size