Prempro / Premphase

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Modified on 2009/10/14 21:46 by admin
Prempro, also known as Estrogens/Medroxyprogesterone Acetate, is an estrogen/progestin combination indicated in women with an intact uterus for the treatment of menopausal symptoms as well as osteoporosis. Prempro is one of the most common medications used by physicians during hormone replacement therapy (HRT). During menopause, a woman's body begins to slow its production of estrogen, which can result in hot flashes, night sweats, vaginal dryness and sleep disturbances.

Estrogen has several beneficial effects in post-menopausal women including minimizing bone loss associated with osteoporosis and preventing the decrease in "good cholesterol" which normally occurs after menopause. Progestin lowers the risk of cancer of the uterus and prevents endometrial hyperplasia, an abnormal or unusual increase in the size of the uterus lining. Both of these disorders have occurred in women using estrogen alone. Prempro was approved by the U.S. Food and Drug Administration (FDA) in 1994 and is made by Wyeth Pharmaceuticals.

Side effects of Prempro use include, but may not be limited to, sharp chest or lower leg (calf) pain, breast lumps, severe headache, shortness of breath, coughing up blood, severe stomach pain or swelling, abnormal vaginal bleeding, mild dizziness, nausea and fluid retention.

In July 2002, The National Institute of Health (NIH) stopped a 16,608-woman study on the benefits of hormone replacement therapy three years early, concluding that hormones such as estrogen and progestin place women who still have their uterus at risk of developing invasive breast cancer. Women involved in the trial had been taking Prempro or a placebo for five years before the study was halted. The study found that women using the hormone drug also faced an increased risk of stroke, heart disease and blood clots.

In June 2003, new analysis of data from the Women's Health Initiative found that Prempro causes abnormal mammograms.


See your doctor if you have experienced serious health problems after undergoing Prempro therapy. In addition, it may be important to contact an attorney who can help you protect your legal rights. Please keep in mind that there may be time limits within which you must commence suit.



See Also

  1. Hormone Replacement Therapy (HRT)
  2. Balance Problems: Overview
  3. Blood Clots
  4. Cancer
  5. Headaches
  6. Heart Problems
  7. Stroke
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