Eloxatin / Oxaliplatin: Overview

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Modified on 2009/10/14 21:45 by admin
Eloxatin, also known as Oxaliplatin, is indicated for the treatment of patients with colorectal cancer whose disease has recurred or become worse following initial therapy with a combination of irinotecan with bolus 5-FU and leucovorin. The combination including Eloxatin was shown to shrink tumors in some patients and delay resumed tumor growth.

Using a "rolling review" procedure, the U.S. Food and Drug Administration (FDA) reviewed the marketing application for Eloxatin in seven weeks, the fastest review to date for a cancer drug. Under the policy, cancer drugs that have the potential to be an advance in treatment are allowed to be sold before there is proof they actually prevent or delay death.

Approved in August 2002, Eloxatin was developed and will be distributed by the French pharmaceutical company Sanofi-Synthelabo. Common side effects of Eloxatin use include, but may not be limited to, vomiting, diarrhea, anemia, increased risk of bleeding or infection, or allergic reaction. Women should be advised to avoid becoming pregnant while receiving this treatment, because it may cause harm to the fetus.

Eloxatin is intended for use by physicians experienced in the use of cancer agents. A black box warning detailing this use and highlighting anaphylactic-like reactions associated with Eloxatin is included in the labeling. Eloxatin can have a toxic effect on nerve endings that may result in either an acute or cumulative pattern of side effects. This may result in the feeling of numbness or tingling, especially in the hands or feet or around the mouth or throat. For some patients these symptoms may be worsened by exposure to cold. This side effect usually occurs within hours or days of dosing.

If you have experienced serious health problems after taking Eloxatin, it may be important to contact an attorney who can help you protect your legal rights. Please keep in mind that there may be time limits within which you must commence suit.



See Also

  1. Cancer Drugs: Overview
  2. Anemia
  3. Diarrhea: Overview
  4. Excessive Bleeding: Overview
  5. Infections
  6. Nausea: Overview
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