Cafergot / Ergotamine Tartrate and Caffeine: Overview

Modified on 2009/10/14 21:52 by admin
Cafergot (ergotamine tartrate and caffeine) treats migraine and cluster headaches by preventing blood vessels in a person's head from expanding. The combination of ergotamine tartrate and caffeine directly influences the smooth muscle of peripheral and cranial blood vessels, producing a vasoconstrictive effect. Made by Novartis Pharmaceuticals, Cafergot comes as a tablet to take by mouth and as a suppository to insert rectally. The U.S. Food and Drug Administration (FDA) approved Cafergot in 1982.

Cafergot may cause fetal harm when administered to pregnant women. The medication is contraindicated in women who are or may become pregnant. Side effects of Cafergot use include, but may not be limited to, upset stomach, vomiting, leg weakness, rapid heartbeat, convulsions or seizures, muscle pain or stiffness in the legs, arms, neck, or shoulders, itching and numbness.

In November 2002, FDA and Novartis strengthened the labeling, including a new BOXED WARNING and updates to the CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, and CLINICAL PHARMACOLOGY sections of the prescribing information for Cafergot. Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of Cafergot with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP 3A4 inhibition elevates the serum levels of Cafergot, the risk for vasospasm (sharp and persistent contraction of a blood vessel) leading to cerebral ischemia and/or ischemia (localized tissue anemia due to the obstruction of the inflow of arterial blood) of the extremities is increased. Because of the increased risk of serious vasospastic adverse events, concomitant use of these medications is contraindicated.

See a doctor if you have experienced serious health problems after taking Cafergot. In addition, it may be important to contact an attorney who can help you protect your legal rights. Please keep in mind that there may be time limits within which you must commence suit.

See Also

  1. Painkillers: Overview
  2. Birth Defects
  3. Heart Problems
  4. Joints & Muscles: Overview
  5. Seizures: Overview
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