Acanthamoeba Keratitis

Modified on 2009/10/14 21:46 by admin
Risk factors for acanthamoeba keratitis: acanthamoeba keratitis typically presents in patients who are in regular contact with non-sterile water, patients wearing contact lenses or having some other corneal foreign body, patients with herpes simplex keratitis, radial keratotomy, bacterial keratitis, and even patients who swim regularly or scuba-dive. Basically, any event disrupting the corneal epithelium presents an opportunity for acanthamoeba keratitis infection.

Symptoms of acanthamoeba keratitis usually include irritation and reddening of the eye. About half of all patients report significant pain in the affected eye. The other half of all patients report minor irritation and a sensation that something is in the eye.

Acanthamoeba keratitis is seldom properly diagnosed in its early stages, and typically the disease must go through a long chronic course in patients before clinicians correctly diagnose acanthamoeba. Clinicians are particularly inclined to diagnose acanthamoeba as herpetic, fungal, or bacterial keratitis. The principal test for acanthamoeba requires cultures of corneal scrapings for diagnosis, but regrettably the diagnostic yield of these cultures is low, and leads to false negatives.

In May 2007, the international optics concern Advanced Medical Optics (AMO) issued a voluntary recall of their Complete MoisturePlus soft contact lens solution due to a link between cases of acanthamoeba keratitis and patients using AMO’s contact lens solution.

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